Mouse α1-protease inhibitor is not an acute phase reactant

Chronic concern over an acute-phase reactant: a teachable moment.

A59-year-oldmanwith a history of shoulder and knee pain presented to our clinic reporting 6 years of left osteoarthritic hippain.Hispainhadbeenprogressive, and at the timeofpresentation,he required theuseofacane for support. The results of radiologic studies showed a loss of joint space with thinning of the upper aspect of the lefthip jointwithbone-on-boneappearanceandsubchondral cyst formation...

Murine serum glycoprotein gp70 behaves as an acute phase reactant

A single intraperitoneal injection of bacterial lipopolysaccharide (LPS) or its lipid A component induced high levels of glycoprotein, gp70, in sera of several strains of mice within 24 h. This serum gp70 response induced by LPS was independent of the activation of B cells and the presence of T cells. However, serological and immunohistochemical studies demonstrated the production of gp70 by he...

Ischemia Modified Albumin as an Acute - Phase Reactant

mean concentration of 0.63 mmol/L, is a powerful acute phase reactant as it changes dramatically during vascular injury and inflammatory processes5. Albumin acts as a buffering agent for endogenous or exogenous toxic molecules due to its various ligands binding ability4,5. The biochemical mechanisms modifying the amino-terminal region of albumin during ischemia are unclear, but reperfusion afte...

Carboxypeptidase N Is Not Protein in the Mouse, Whereas Pro-carboxypeptidase R Is an Acute Phase

Fibronectin is synthesized as an acute phase reactant in rat hepatocytes.

Elevated concentrations of fibronectin were found in plasma of rats under different acute phase conditions. Untreated animals showed a plasma fibronectin concentration of 150 +/- 50 mg/l, which increased to 412 +/- 59 mg/l 24 h after subcutaneous injection of turpentine. The time course of the changes in plasma fibronectin concentration showed a peak at 24 h and a decline to normal concentratio...